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English
[L. acidophilus strain Er-2 317/402 administration reduces Candida albicans and Enterobacteria in the intestinal microbiota of patients with familial Mediterranean fever.]
The study examined the effect of L.acidophilus INMIA 9602 Er 317/402,isolated from the commercial probiotic formulation (Vitamax-E) used by Armenian FMF patients, on the relative abundance of gut enteric bacteria, lactobacilli,S aureus and E faecalis in C albicans-carrier FMF patients with the MEFV pyrin inflammasome mutation M694V/V7262A wich is the prevalent pattern in the Armenian cohort Main reesearch questions were to show if the changes in gut microbiota of FMF patients, primarily associated with the M694V/V726A pyrin inflammasome mutations, could lead to overgrowth of gut C. albicans of the patients and if colchicine/probiotic could effect on gut microbiota of patients through the regulation of NLRP inflammasomes.
Forty healty volunteers with less than baseline of C albicans and without mutation in MEFV and 48 FMF volunteers were enrolled in double-blind, party randomized placebo –controlled trial
Our investigations indicate that the uptake of L.acidophilus INMIA9602 Er317/402 reduces the numbers of yeast in the gut microbiota of FMF patients.
